BACKGROUND:Two liters of polyethylene glycol (PEG) solution Headers/IDC administered with ascorbic acid (Asc) can provide efficacy similar to that of a 4-L PEG solution for colonoscopy preparation.In addition, oral bisacodyl (Bis) has been shown to reduce the volume of PEG needed for a bowel preparation with comparable efficacy.This study aimed to compare the efficacy, tolerability and safety of a 2-L PEG solution mixed with Asc versus the combination of Bis, Asc and a 1-L PEG solution.METHODS:This was a prospective, randomized, multi-centre, single-blind, non-inferiority trial.
Participants who were scheduled for colonoscopy were included and randomized to receive either 2-L PEG and Asc (2L PEG/Asc group) or 1-L PEG, Asc and 20 mg Bis (1L PEG/Asc + Bis group).The quality of bowel preparation was assessed using the Boston Bowel Preparation Scale.Data regarding tolerance, compliance and adverse events were also gathered.RESULTS:A total of 187 participants were analyzed; 96 were allocated to the 2L PEG/Asc group and 91 to the 1L PEG/Asc Rain Jacket + Bis group.
Bowel preparation was adequate in 87.5% (84/96) of patients in the 2L PEG/Asc group and 94.5% of the 1L PEG/Asc + Bis group (86/91, p = 0.10).
There was no significant difference between the two groups with respect to compliance, tolerability or safety.The patients allocated to the 1L PEG/Asc + Bis group expressed more willingness to repeat the procedure than patients in the 2L PEG/Asc group (p = 0.01).CONCLUSIONS:Bowel preparation with Bis and a 1-L PEG/Asc solution is as effective, well-tolerated, and safe as a 2-L PEG/Asc solution.
TRIAL REGISTRATION:ClinicalTrials.gov NCT 01745835; Clinical Research Information Service (CRiS) KCT0000708.